ICSI (Intracytoplasmic Sperm Injection)

Intracytoplasmic sperm injection (ICSI) is a new procedure that allows couples with sperm problems to have IVF treatment. Developed in Belgium in 1992, ICSI is the process of injecting a single sperm into an egg.

It is a remarkable procedure since it allows men with only very few sperm to have a chance of having their own children.

• What is the normal process of fertilization during an IVF cycle?
• Will my sperm be able to fertilize our eggs?
• What does ICSI involve?
• Is ICSI a safe procedure?
• Who can I talk to if I have further questions?

What is the normal process of fertilization during an IVF cycle?

The eggs that are collected from your ovaries are kept in special incubators in the IVF laboratory. Your sperm sample is processed to recover the strongest and best swimming sperm to be used to inseminate the eggs. Poorly swimming and dead sperm are discarded as medical waste. Because the egg has a thick shell and is surrounded by thousands of follicle cells, the Embryologist will usually add about 100,000 sperm to each egg. Adding so many good sperm to each egg disperses the follicle ensures that one sperm will get in to fertilize the egg.

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Will my sperm be able to fertilize our eggs?

All couples having IVF treatment will have their sperm sample analyzed by the laboratory staff. As well as checking the basic parameters of the sperm sample, such as count and motility, the laboratory will examine how well the sperm are swimming and whether or not the sperm are physically normal. It is important that the sperm are strong swimmers and that they are the correct shape to be able to reach and penetrate the egg.

In general, men with "normal" sperm samples have nothing to worry about and do not need ICSI. However, if we think that you need ICSI we will talk to you after we examine your sperm sample. Any man that has had consistently poor sperm samples, and men that need to have their sperm recovered surgically will always need ICSI.

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What does ICSI involve?

If a decision has been made by you and your Physician to have ICSI, the laboratory will get specific instructions on how many eggs to inject. Sometimes, couples with borderline sperm samples will decide to have some eggs injected and some inseminated normally.

In the laboratory, the follicle cells are removed from around each egg with an enzyme solution. One by one, the naked eggs are held by gentle suction on a glass holding pipette, and a single sperm is injected. The tiny glass needle containing the sperm is gently pushed through the shell of the egg and the sperm is deposited in the egg cytoplasm.

Suction applied by a glass holding pipette keeps the egg from moving during the injection. A single sperm is picked up in a tiny microneedle. The needle has a sharp tip and can be gently pushed through the shell of the egg and into the cytoplasm. The sperm is deposited deep inside the egg and the empty needle is withdrawn.

Why Us

Fertility & Responsibility

The aim at the Gynaecworld is to achieve the highest possible standards in all aspects of medical practice. The approach has always been to maximise your chance of a live pregnancy, without exposing you to the risk of multiple pregnancies. A conservative, clinical approach that aims to minimise medical and surgical intervention, yet offers you the optimum treatments and options available. In fact, the centre’s success is assessed by the number of successful, safe and single pregnancies achieved.

Fertility & Excellence

The skill and experience of our team of leading consultants has ensured that the Unit is at the forefront of clinical excellence. Our laboratory is being continuously updated to include equipment for handling gametes, freezing sperm, and embryos, and microinjection. We have highly accomplished embryologists and a considerable amount of time and effort has been invested in the Laboratory in order to maintain the highest possible standards.

Fertility & Support

The team at Gynaecworld understands that fertility treatment can be an extremely stressful and emotional experience. To ease it out for you, at every stage of the process, counsellors are more than willing to listen, explain and reassure. You will always find warmth, support and invaluable guidance from a dedicated team of doctors and nurses. They are ready to explain treatment options, as well as day-to-day treatments and procedures, and even teach you to self administer injections, increasing their convenience and comfort.

Fertility options Under One Roof

At Gynaecworld, we understand the value of your time. Therefore, we cater to all your requirements under one roof.Consultation and monitoring with the gynaecologist, ultrasounds, laboratory investigations, sessions with the counsellor, appointments with the andrologist, ovum pick up and embryo transfers (in the operation theatre), are all done under one roof
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Overseas Program

	We understand the anxiety and problems that our overseas couples may experience. Therefore, we have a special Overseas Program (OP) to make them comfortable. This program has a few unique characteristics, such as
	Door to door services
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	Co-ordination of cycles whilst you are in your own country
	Limiting your stay in Mumbai to the minimum
	Staying in constant touch during the IVF program
	Emailing copies of the Surrogate’s reports, including scans of the baby throughout the pregnancy.
	Provision of accommodation through our travel organiser
	Payment in instalments according to the trimesters of pregnancy
	Direct payment to the Surrogate. The center does not interfere in the transaction of money between you and the surrogate

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What is PCOS

In each menstrual cycle, follicles grow on the ovaries. Eggs develop within those follicles, one of which will reach maturity faster than the others and be released into the fallopian tubes. This is "ovulation". The remaining follicles will degenerate.In the case of polycystic ovaries, however, the ovaries are larger than normal, and there are a series of undeveloped follicles that appear in clumps, somewhat like a bunch of grapes. Polycystic ovaries are not especially troublesome and may not even affect your fertility.

However, when the cysts cause a hormonal imbalance, a pattern of symptoms may develop. This pattern of symptoms is called a syndrome. These symptoms are the difference between suffering from polycystic ovary syndrome and from polycystic ovaries.

So you can have polycystic ovaries without having PCOS. However, nearly all women with PCOS will have polycystic ovaries. Polycystic Ovary Syndrome is the name given to a metabolic condition in which a woman will have polycystic ovaries, along with a certain pattern of other symptoms that reflect imbalances in reproductive and other hormones.

Let’s define some terms:

• "Syndrome" simply means a set of symptoms that occur together, in a pattern.
• "Polycystic" means there is an accumulation of incompletely developed follicles (cysts) in the ovaries
• "Polycystic ovarian syndrome" refers to a health disorder where there may be many cysts in the ovaries, accompanied by a distinctive pattern of symptoms.
• "Metabolic" refers to the physical and biochemical processes required for the body to function.
• "Polycystic ovary syndrome" is the name given to a metabolic condition in which a woman will have cystic ovaries, along with a certain pattern of other symptoms that reflect imbalances in reproductive and other hormones.

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