Zollinger-Ellison Syndrome is an uncommon problem affecting various internal organs in the digestive system. It causes production of excessive acid in the pancreas or duodenum causing ulcers that may turn cancerous as well. ZES generally affects men aged 30 – 50 years more than any other population group. Population suffering from a genetic disorder known as multiple endocrine neoplasia type 1 (MEN1) are highly susceptible for this affliction. MEN1 is hereditary and children of parents with MEN1 have higher risk of inheriting MEN1 and in turn have increased chances of getting ZES.
ZES is caused by the release of Gastrinomas. The actual reason behind appearance of Gastrinomas has still not been ascertained except for the fact that this disorder is hereditary. Almost one in four Gastrinoma causes are a hereditary gene problem known as multiple endocrine neoplasia type 1 (MEN1). These tumors produce a hormone known as Gastrin. Gastrin causes various cells in the stomach to generate Gastric juice. Gastric juice is acidic in nature and is used to breaking down food for digestion. When created in excess amounts, it has adverse effects on the inner lining of the various digestive organs. Sores known as peptic ulcers appear on the inner lining of the duodenum.
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