Nexium Interactiоns

There are some medications that Nexium can interact with. While some are given below, there may be others about which your physician or pharmacist would be able to give you more information.
If antiretroviral drugs such as Atazanavir and Nelfinavir are given alongwith Esomeprazole, it can bring down serum levels, and neither of these is recommended with Nexium.
Another antiretroviral drug, Saquinavir, if given with Esomeprazole, can increase serum levels; if necessary, it has to be given cautiously.
Voriconazole is not recommended with Esomeprazole, as it doubles the effect of the latter.
Should Warfarin or Cilostazol be given alongwith Esomeprazole, careful monitoring is required.
Esomeprazole also interacts with Ampicillin, Calcium supplements, azole anti-fungals like Ketoconazole, Digoxin, or Iron Salts, as Esomeprazole reduces the acid in the stomach that leads to decreased absorption of these drugs.
A combined therapy of Clarithromycin, Amoxicillin and Esomeprazole can raise plasma levels of Esomeprazole. In some patients, Clarithromycin has no effect on H.pylori bacteria, and this combined regimen is of no benefit to them. For pregnant women, usage of Clarithromycin is not recommended, as it may harm the fetus. It is given only in special circumstances [under strict medical supervision] when no alternative therapy is available.